Chicago-based biofabrication company Dimension Inx recently announced a major milestone in its journey towards revolutionizing the field of regenerative medicine. Their FDA-approved 3D printed regenerative bone graft product, CMFlex, has been successfully used in its first two clinical cases.
The CMFlex synthetic bone graft is specifically designed to treat various bony defects in oral and maxillofacial surgical applications. What sets CMFlex apart is its unique three-dimensional architecture, which incorporates macro, micro, and nano-level features that promote bone regeneration.
The two surgical procedures in which CMFlex was utilized included a mandibular angle augmentation and a maxillary segmental osteotomy. These surgeries were performed by Dr. Derek Steinbacher and Dr. Brian Farrell, both renowned practitioners in the field of oral and facial surgery.
Dr. Adam Jakus, CTO and Head of Technology Strategy at Dimension Inx, highlighted the significance of these first clinical cases, stating that they not only demonstrate the potential of the company’s biomaterials but also showcase the capability of their technology platform to create biomaterials that restore tissue and organ function. Dr. Ramille Shah, CSO and Head of R&D at Dimension Inx, expressed excitement about sharing CMFlex with the surgical community and emphasized the product’s ability to restore functionality through a combination of biology, material composition, microstructure, and macroarchitecture.
CMFlex is the first 3D printed regenerative bone graft product to receive FDA clearance. While currently available to a limited number of surgeons, Dimension Inx plans to expand its availability in 2024. The bone graft product is made from a combination of hydroxyapatite particles and biodegradable polylactide-glycolide (PLG) polymer, both known for their biocompatibility and clinical utility. These materials are combined into a proprietary composite material called Hyperelastic Bone, which is then 3D printed into CMFlex. The resulting product can be customized in size to meet the specific needs of each patient. CMFlex also has excellent fluid absorption properties, allowing it to control bleeding during surgery and aid in the bone remodeling process post-implantation.
Surgeons who have used CMFlex have praised its handling characteristics and its ability to be easily cut and shaped to match defect sites. Dr. Robert Bosack, a practitioner specializing in oral, maxillofacial, and dental implant surgery, mentioned being impressed with the product’s ability to promote hemostasis, simplifying the implantation process.
This achievement by Dimension Inx represents a significant advancement in the field of medical 3D printing, particularly in bone-related procedures. The potential of 3D printing in regenerative medicine continues to expand, with ongoing research to optimize 3D printed bioabsorbable implants for bone healing.
In Europe, medical device manufacturer Cerhum has already received approval for its 3D printed bone graft product, called MyBone. This bone graft, created through a patient-specific process, is now available to orthopedic and maxillofacial surgeons across the continent.
The progress made by Dimension Inx and other companies in the field demonstrates the transformative impact of medical 3D printing. As this technology continues to advance, we can expect more breakthroughs in regenerative medicine and personalized healthcare.
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In this blog post, we will explore CMFlex’s groundbreaking three-dimensional architecture, as captured in the featured image from Dimension Inx.
3D printing has emerged as a revolution in the world of manufacturing, enabling designers and engineers to create complex, intricate structures that were previously unimaginable. With advancements in technology, materials, and techniques, the possibilities are endless.
CMFlex’s three-dimensional architecture stands as a testament to the incredible potential of 3D printing. This innovative approach displays a level of flexibility and strength that surpasses traditional methods. By utilizing a combination of biocompatible materials, CMFlex has successfully created a structure that mimics the intricacies of natural tissue.
The implications of this breakthrough are immense. Imagine the potential for organ transplantation, where 3D printing could help develop custom organs tailored to individual patients. Not only would this revolutionize the medical field, but it could also save countless lives and reduce the need for organ donors.
Furthermore, CMFlex’s technology opens up new possibilities in the field of robotics. The ability to create flexible structures with enhanced strength and durability could pave the way for advancements in prosthetics and exoskeletons.
This development also highlights the importance of staying up to date with the latest news and innovations in 3D printing. By following industry leaders on social media platforms and subscribing to relevant channels, you can gain valuable insights and stay connected with this rapidly evolving field.
So, whether you are a professional in the additive manufacturing industry or simply intrigued by the possibilities of 3D printing, be sure to stay connected and continue exploring the endless potential of this groundbreaking technology.
“Why did the 3D printer go to therapy? Because it had too many layers of unresolved issues!”
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